[Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine]. - École des Ponts ParisTech Access content directly
Journal Articles Thérapie Year : 1970

[Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine].

Abstract

A mitochondrial dysfunction has been suggested to explain chronic renal toxicity observed in ciclosporine A therapy. Our study has investigated whether trimetazidine allows inhibition of mitochondrial alteration induced by ciclosporine A. Oxidative phosphorylation was measured by polarography, calcium fluxes by a specific calcium electrode and the mitochondrial swelling by determination of the optical density at 520 nm, using a spectrophotometer. The ciclosporine A effect on the respiratory control was fully inhibited by trimetazidine (EC50 5.10 x 10(-7) M; Emax 11 per cent). Trimetazidine also inhibited the ciclosporine effects on calcium fluxes, i.e. calcium accumulation into the matrix and delay of efflux. Trimetazidine allows a decrease of mitochondrial dysfunction induced by ciclosporine A.
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Dates and versions

hal-02268288 , version 1 (20-08-2019)

Identifiers

  • HAL Id : hal-02268288 , version 1
  • PUBMED : 11806297

Cite

C. Simon, Christophe Morin, B Bruguerolle, J. Tillement. [Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine].. Thérapie, 1970, 56 (5), pp.583-7. ⟨hal-02268288⟩
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