This study examines the impacts of climate change on the herpetophauna of wetlands of the Middle Dnipro ecological corridor, including territories of Rzhyshchiv CATC, Ukraine. Our ongoing studies since 2009 in the Rzhyshchiv CATC territory have reported 11 species of amphibians and 7 species of reptiles. These territories are crucial for biodiversity conservation, acting as a refuge with unique microclimate and conditions for flora and fauna. However, climate change introduces transformations that can negatively affect this complex ecosystem. The impacts of climate change on amphibians and reptiles remain under-studied due to the lack of long-term monitoring. Many existing studies use temporary phenomena and facts, which complicate future forecasting and recommendations. Climate change includes increasing air temperature and altered precipitation patterns. These changes can cause fluctuations in water levels, changes in water resources distribution, and in soil moisture. The main consequences of climate change and anthropogenic pressures on the investigated region could include: loss of habitats and breeding grounds for animals (most water bodies have dried up); changes in the spatial structure of animal populations (due to drought, some amphibian species have migrated to other places); emergence of invasive species (invasive predatory fish can pose a threat to young amphibians); appearance of individuals with anomalies (several types of anomalies have been detected); changes in the range boudaries of animal species (new thermophilic species for this territory have appeared due to warming – e. g. N. tessellata, etc.). These findings underline the importance of continued research and monitoring to understand the full extent of climate change impacts on these ecosystems and develop effective conservation strategies.